For hypovolemia and hypoalbuminemia, ALBURELTM 20% is a hyperoncotic solution from US-FDA approved source of Human Albumin paste following strict aseptic processing conforming to WHO norms of Current Good Manufacturing Practices (CGMP).
In the care of a critically-ill patient suffering from excessive blood loss, edema, or massive burn, a special colloidal preparation has been proven effective in filling fluid volume in the cardiovascular system and improving albumin levels. Plasma Volume Expanders (PVE) do just that. Gone are the days when lives are lost due to poor hemodynamic status which arises from absence of blood substitutes that are readily available nowadays.
What is AlburelTM and how does it work?
AlbuRelTM is a Plasma Volume Expander (PVE) used to increase the circulating plasma volume in blood. Albumin is the most abundant protein in human plasma and is synthesized by the liver. Plasma exchange, dialysis, burns, cerebral edema, cirrhosis of the liver, and hypovolemic shock are some the many indications where Albumin preparations can be used. AlbuRelTM is available in 20% (hyperoncotic) and 5% (iso-oncotic) concentrations in 50ml or 100 ml pack size. It is given intravenously with or without dilution. In diluted form, it may be given with normal saline or 5% glucose before administration. The clinician should determine appropriate therapy after clinical assessment of the patient. Dosages differ for each indication as well.
AlburelTM by Reliance Life Sciences (http://www.rellife.com/) is exclusively distributed by Ambica International Trading Corp. (www.ambicaphilippines.com). For more information, you may visit our main office #9 Amsterdam Extension, Merville Park Subd.Paranaque City, Philippines 1700 or contact us through our landline numbers: (632) 828-6617 | (632) 828-6618 | (632) 828-6542 | (632) 211-6690; Fax No.:(632) 828-6615. You may also email us at ambica@pldtdsl.net.
Frequently Asked Questions:
Where does Human Albumin IV come from?
AlburelTM comes from pooled plasma obtained from US-FDA approved blood banks and pharesis centers. It undergoes several steps and processing. Albumin is isolated using Cohn’s fractionation, a widely accepted method of extracting albumin from blood plasma. To ensure very minimal risk of any contamination, it undergoes double pasteurization.
What is the risk of getting infection from Human Albumin?
The risk is very remote. This is because AlburelTM is made with utmost care and safety in mind. Aside from obtaining human albumin paste from trusted blood banks, the purified albumin bulk is pasteurized at 60 oC for 10 hrs. Any presence of bacterial or viral contamination is checked using polymerase chain reaction (PRC) technology of Reliance Life Sciences. The final filled product once again undergoes viral inactivation by pasteurization at 60 oC for 10 hrs (double pasteurization) and is checked for any contaminant via PCR. External agencies are also involved in process validation.
Reliance Life Sciences (manufacturer) ensures that their facility conforms to the World Health Organization (WHO)-Current Good Manufacturing Practices (CGMP). Throughout the manufacturing process, aseptic technique is observed. Stringent quality control like sterility, pyrogenicity, and toxicity of final products is guaranteed in every AlburelTM vial.
How does Human Albumin work?
Albumin is part of the normal blood component. It is most abundant in our plasma, contributing to what we call “oncotic pressure”. Oncotic pressure is the tendency of a substance—one very good example is albumin— to draw water towards its concentration. So if a person who has low blood volume (hypovolemia) is given albumin intravenously (directly in the blood vessel), then the albumin draws or attracts the water or fluid to go inside the blood vessels. This contributes to the volume expansion and subsequent elevation of blood pressure.
What are the uses of Human Albumin?
These are just some uses or indications for giving human albumin—hypovolemia, hypoalbuminemia, hepatorenal syndrome, hyperbilirubinemia, ascites, spontaneous bacterial peritonitis, liver cirrhosis, subarachnoid hemorrhage, and sepsis.
What is the difference between 20% and 25% Human Albumin preparation?
Both are hyperoncotic and are very useful in patients with hypovolemia. Their use is basically the same. They only differ in the amount of colloid oncotic pressure (COP). The corresponding volume expansion effect of 20% albumin averages 210% [1], [2] and 25% albumin 260% [1], [3], [4] based on several studies. The use of albumin 20% is widely accepted in other countries (Europe and United States). In some institutions, they use human albumin 20% which is said to increase albumin level while minimizing risk of fluid overload [5].
As for the price, AlburelTM is more affordable than other human albumin products in the market. It doesn’t sacrifice quality and effectives but delivers the same hyperoncotic property at a more affordable price.
Sources: